Drs. Martin Leon and Dan Burkhoff Discuss Hemodynamics of Protected PCI with Impella

December 3, 2015

In the video below, the Cardiovascular Research Foundation presents a discussion between Drs. Martin Leon and Dan Burkhoff from Columbia University, New York, NY entitled “Understanding the Hemodynamics of Protected PCI with Impella.”

Dr. Leon begins the discussion with a brief history of interventional cardiology from the 1980’s to the present day and the latest development—the Impella heart pump, which allows Protected PCI in complex higher-risk and indicated patients (CHIP). CHIP patients are those with severe coronary artery disease who are hemodynamically stable, have a depressed left ventricular ejection fraction of ≤35%, and comorbid conditions such as heart failure, peripheral vascular disease, complex lesions, diabetes, advanced age, and unstable angina.

The highlight of the discussion is Dr. Burkhoff’s presentation of the Harvi simulator, which shows pressure volume loops, aortic pressures, and coronary blood flow heartbeat-by-heartbeat. Dr. Burkhoff provides detailed explanations of the heart function of simulated patients under three conditions: no hemodynamic support, support with the intra-aortic ballon pump (IABP), and the use of the Impella, a left ventricular assist device. The Harvi simulator enables physicians to visualize what is happening in the heart and understand the hemodynamics under each of these conditions. The Harvi simulator was showcased using the data derived from real life clinical cases, which were presented by Dr. Burkhoff and discussed with Dr. Leon.

The Harvi simulator allows clinicians to understand that the primary difference between the IABP and the Impella is the type of support provided: IABP supplements the heart’s actions while the Impella heart pump maintains hemodynamic support independent of contractility, which uncouples ventricular and systemic perfusion. Clinical trials from the Impella Registry are presented, which indicate that the Impella heart pump maintains hemodynamic support, and may allow for a more complete revascularization.

Complete revascularization is the therapeutic goal of Protected PCI. The benefits of complete revascularization include increased left ventricular function, decreased major adverse cardiovascular and cerebrovascular events (MACCE), and fewer repeat revascularizations, among other outcomes.

View this demonstration of the Harvi tool now by watching the video above or by clicking here.


To learn more about the Impella® platform of heart pumps, including important risk and safety information associated with the use of the devices, please visit: www.protectedpci.com/indications-use-safety-information/

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