mortality remains high for STEMI patients

Mortality Remains High for STEMI Patients Complicated by Cardiogenic Shock

December 2, 2016

Key Takeaways

  • Early reperfusion for STEMI patients complicated by cardiogenic shock results in lower mortality compared to prolonged reperfusion.
  • Shorter onset-to-balloon (OTB) and door-to-balloon (DTB) times are recommended to improve patient survival.
  • A shorter OTB was associated with longer overall survival in patients vs prolonged OTB (43.3% and 55.5%, respectively).
  • Mortality rates for short vs long DTB in this study were 44.9% and 55.8%, respectively.

The significant reduction of in-hospital mortality related to ST-segment elevation acute myocardial infarction (STEMI) has been greatly attributed to the overwhelming adoption of primary percutaneous intervention (PCI). STEMI patients with cardiogenic shock (CS) tend to experience a higher mortality even after PCI and the implantation of mechanical circulatory support (MCS) devices.

A recent retrospective study published in European Heart Journal: Acute Cardiovascular Care assessed the mortality benefit, if any, of reperfusion via primary PCI for patients with STEMI complicated with CS of 466 patients enrolled in the Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) acute myocardial infarction (AMI) registry.

For the purpose of this study, CS was defined by the following Killip class IV criteria:

  • Systolic blood pressure < 90 mmHg
  • Vasoconstriction manifestations
    • Cyanosis
    • Diaphoresis
    • Oliguria

To evaluate the primary outcome measure of all-cause mortality for these patients, researchers looked at the cumulative incidence of all-cause death in the patients with STEMI complicated by CS due to acute pump failure. The recorded incidence was as follows:

  • 25.4% at 30 days
  • 38.7% at 12 months
  • 51.4% at five years

Researchers found that a shorter onset-to-balloon (OTB) time (< 3 hours) resulted in a significantly lower rate of death (Figure 1) compared to prolonged OTB (43.3% and 55.5%, respectively). There were similar findings between short and long door-to-balloon (DTB) time (44.9% vs 55.8%, respectively). Additionally, early reperfusion was associated with a lower rate of mortality.

Figure 1. All-Cause Mortality of Short and Prolonged (a) OTB and (b) DTBa
long term clinical outcomes
aData from Kawaji, Shiomi, Morimoto, et al.1

While the patient population used in this study was relatively small (n=3942), the data shows mortality rates continue to remain high among patients with STEMI complicated with CS caused by acute pump failure. Implementing shorter OTB and DTB times, at least according to this study, may result in improved long-term survival.

Reference:

  1. Kawaji T, Shiomi H, Morimoto T, et al. Long-term clinical outcomes in patients with ST-segment elevation acute myocardial infarction complicated by cardiogenic shock due to acute pump failure. Eur Heart J Acute Cardiovasc Care. 2016.

To learn more about the Impella® platform of heart pumps, including important risk and safety information associated with the use of the devices, please visit: www.protectedpci.com/indications-use-safety-information/

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